Rejuran
Consultations offered at our seven convenient locations in Brea, Costa Mesa, Glendora, Lancaster, Rancho Cucamonga, Whittier and West Hollywood

Rejuran (Rejuran®) is an innovative injectable that can rejuvenate your appearance by improving your skin’s tone and texture with polynucleotides derived from salmon DNA. If you want to address fine lines, wrinkles, and/or loss of elasticity, this effective treatment can help you achieve your goals with ease. With Rejuran, you can renew your appearance without drawing blood, using artificial fillers, or making any incisions. Rooted in the principles of K-beauty (Korean beauty), Rejuran reflects a scientifically advanced, non-invasive approach to skincare that emphasizes natural rejuvenation and radiant, healthy-looking skin.
Skin Perfect offers innovative beauty treatments that have helped thousands of patients enhance the appearance of their skin and diminish signs of aging. We can personalize your treatment plan with customizable therapies to tailor your treatment to your unique concerns. Rejuran can help you achieve dewy skin and that “glass skin” look with simple injectables that require minimal downtime for beautiful results.
Schedule a consultation online to explore your Rejuran treatment possibilities. If you have any further questions, please call any of our locations directly.
- Whittier: (562) 278-3202
- Rancho Cucamonga: (909) 281-9020
- Brea: (714) 278-3501
- Costa Mesa: (714) 278-3506
- West Hollywood: (323) 373-3149
Contents
About Rejuran and PDRN
Rejuran can help your skin repair itself by producing new cells with polynucleotides, a key component of salmon sperm. Polynucleotides are compounds composed of purified DNA fragments. PDRN (polydeoxyribonucleotide), a key component of Rejuran, helps to increase cellular regeneration and help regulate your body’s gene expression. (1) It has anti-inflammatory properties and is clinically proven to help the body repair vital tissues, including bone tissue. (2) Rejuran contains a purified form of salmon DNA that is well-tolerated and biocompatible to reduce the risk of skin irritation. This gentle formula can address signs of aging, reducing fine lines and wrinkles for a smoother, more youthful look. It can also improve your skin’s elasticity with lasting results.
Rejuran vs Dermal Fillers
Unlike dermal fillers that add volume to your skin, Rejuran rejuvenates your skin by helping it produce new cells. Many patients choose Rejuran to address signs of aging or skin damage, while dermal fillers are more effective for adding volume. If you have sensitive skin, an allergy to the ingredients in fillers, or would like to refresh your skin without adding volume, Rejuran is likely a good fit for you.
Rejuran vs. Exosomes
Exosomes are small extracellular vesicles that can help your skin repair itself by improving cellular communication. They are smaller than a cell, and the body’s nervous system, connective tissues, and immune system naturally produce them. They can improve your immune response by calling attention to areas that need support. We can administer exosomes to your skin with Rejuran or as a stand-alone treatment to help your skin repair itself from damage. The treatment can also increase the collagen levels in your skin for a smoother look and long-lasting results.
Benefits
There are several benefits to receiving Rejuran, including:
- Smoother, more youthful-looking skin: We can diminish the appearance of fine lines and wrinkles for a more youthful look.
- Long-lasting results: Patients can enjoy results that last as long as six months to a year. We can help you maintain your results with a touch-up appointment.
- Minimally invasive treatment: We can transform your appearance with a simple injectable that requires minimal downtime.
- Well-tolerated procedure: The treatment is ideal for a variety of skin types, and it can also treat sensitive skin.
- Increased collagen levels: We can increase your skin’s collagen levels for a smoother, more youthful-looking appearance and natural-looking results.
Candidates
Suitable candidates for Rejuran are those who would like to address fine lines, wrinkles, and/or loss of skin elasticity. This treatment is also highly recommended if you are interested in hydrating your skin and improving its texture. You should keep realistic expectations about the treatment, and you will need to consistently take good care of your skin for optimal results.
Schedule a consultation online to learn more about how we can enhance your skin.
Consultation
During your consultation, we will ask about your aesthetic goals, medical history, and current medications. We will personalize a treatment plan for your specific needs after collecting the necessary information.
We can also combine Rejuran with other treatments to help you achieve your aesthetic goals. We offer several anti-aging rejuvenation treatments that we can combine with Rejuran. To learn more about our additional treatments, please read our blog!
Preparation and Treatment Process
To prepare for Rejuran, you must stop taking medications or supplements that thin your blood. You should also avoid excessive sun exposure that could damage your skin in the weeks leading up to your appointment. On the day of your appointment, you will need to arrive with clean skin, free from any makeup or skincare products.
Each patient’s treatment process will vary depending on the personalized plan received. When performing a Rejuran treatment, we administer the formula with a thin needle. We can address multiple areas in one treatment session.
After Your Treatment
About 2-4 weeks after your treatment, you will be able to enjoy more youthful-looking skin. We can provide specific instructions to help you care for your skin afterward. During this time, you will need to avoid excessive sun exposure to prevent skin damage.
Klardie
Klardie is a collection of medical-grade Korean skincare products that nourish the skin with nutrient-rich serum. The collection contains Hyalusome™️–a cross-linked form of hyaluronic acid that hydrates the skin for a plumper appearance. We can combine Klardie with facials or recommend an at-home care routine to help you enhance the results of your Rejuran injections.
Results
The results of Rejuran are long-lasting as long as you care for your skin. Most patients notice optimal results after approximately 4 weeks. (3) If you experience changes to your skin after receiving Rejuran, we can help you maintain your results with a touch-up appointment.
Corresponding Procedures
Botox Botox is a neuromodulator that reduces acetylcholine to diminish the appearance of fine lines and wrinkles for smoother skin. As you age and your skin’s collagen levels decline, fine lines and wrinkles are common. With Botox, you can enjoy smoother skin with a simple injectable, and we can help you maintain your results with touch-up appointments throughout the year.
Fillers
Fillers add natural-looking volume to the skin for a smoother, plumper appearance and a more youthful look. We offer several different formulas to address volume loss in common areas. As you age, volume loss is especially common near the temples and eyes. Some patients also experience volume loss near the cheeks. With fillers, we can balance your facial proportions for beautiful, long-lasting, natural-looking results.
Microneedling
Microneedling is a skin rejuvenation treatment that raises your skin’s collagen levels to refresh your appearance. The treatment can diminish the appearance of wrinkles and fine lines for a more youthful look. If you have sun damage, discoloration, and/or acne scars, we can also address them for smoother, more even skin. During the treatment, we will administer tiny needles to the skin that penetrate the skin barrier to trigger your body’s healing response. Many patients receive a series of microneedling treatments to help them refresh their skin.
Cost of Rejuran in Rancho Cucamonga

The cost of Rejuran will depend on your personalized treatment plan and whether you need additional treatments to achieve your aesthetic goals. We can provide an all-inclusive quote and personalize your plan based on your specific needs. We can also discuss financing to help make your treatment more accessible. We also offer memberships for regular specials and discounts on treatments.
Schedule a consultation online to learn more about how our transformative treatments can renew your skin. If you have any further questions, please call your closest Skin Perfect office directly:
- Whittier: (562) 278-3202
- Rancho Cucamonga: (909) 281-9020
- Brea: (714) 278-3501
- Costa Mesa: (714) 278-3506
- West Hollywood: (323) 373-3149
FAQ
Is there any downtime after Rejuran?
Although you will need to avoid excessive sun exposure that could damage your skin, you can return to most of your normal activities afterward. However, if you receive additional treatments, we may recommend that you schedule downtime as necessary.
How long do the results of Rejuran last?
This will depend on the condition of your skin and how you care for it afterward. We can provide specific instructions to help you care for your skin effectively after your treatment for the best results.
Are there any side effects associated with Rejuran?
You may experience some slight skin irritation near the injection site. However, this is temporary, and if you experience discomfort, you can alleviate it with a cold compress.
Can Rejuran be combined with other treatments?
Yes, many patients choose to combine Rejuran with other treatments such as skin rejuvenation and/or facials to refresh their appearance. During your consultation, we can discuss the most effective plan for your specific aesthetic goals.
References
- Alvin W, Chan L, Lee A, et al. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. International Journal of Molecular Sciences. 2024;25(15):8224-8224. doi:https://doi.org/10.3390/ijms25158224
- Squadrito F, Bitto A, Irrera N, et al. Pharmacological Activity and Clinical Use of PDRN. Frontiers in Pharmacology. 2017;8. doi:https://doi.org/10.3389/fphar.2017.00224
- Pak CS, Lee J, Lee H, et al. A Phase III, Randomized, Double-Blind, Matched-Pairs, Active-Controlled Clinical Trial and Preclinical Animal Study to Compare the Durability, Efficacy, and Safety between Polynucleotide Filler and Hyaluronic Acid Filler in the Correction of Crow’s Feet: A New Concept of Regenerative Filler. Journal of Korean Medical Science. 2014;29(Suppl 3):S201-S209. doi:https://doi.org/10.3346/jkms.2014.29.S3.S201