Dermal Fillers & Injectables

An injectable treatment, including dermal fillers, is one of the most popular non-surgical rejuvenation options available. Whether the goal is to smooth wrinkles, replace volume, or boost collagen, each of these can reduce signs of facial aging and restore a more youthful-looking appearance. Each injectable option contains different materials, providing distinct benefits and achieving varying effects against the concerns that worry you most.

Since 2004, Skin Perfect has been helping patients across Southern California rejuvenate their appearance. Our expert team members offer a wide array of different anti-aging treatments, fillers, neurotoxins, and injectables, allowing each individual who enters our care to achieve refreshing results that look and feel like them—but better.

To get started at any one of our locations, please contact us online or call the office of your choice!

Xeomin

Restylane Kysse

PDO Thread Lift

Restylane Refyne & Defyne

KYBELLA

Sculptra®

Restylane Lyft

Dysport

Radiesse

Juvéderm

Restylane

Botox

About Dermal Fillers and Injectables

Dermal fillers and injectables are non-surgical, minimally invasive treatments that can rejuvenate, refill, and recontour through simple injections. Each targets a different concern through varying mechanisms, such as addressing wrinkles, enhancing certain features, dissolving fat, stimulating new collagen, and more. At Skin Perfect, we offer a wide range of injectables, including fillers, biostimulators, and neurotoxins, allowing you to create an injection plan that is as unique as you are.

What is the Difference Between Dermal Fillers, Biostimulators, and Neurotoxins?

When researching different injectables, it can be confusing to understand the differences between each option. By understanding the differences between dermal fillers, biostimulators, and neurotoxins, you can make the best choice for your appearance goals.

Dermal Fillers

Dermal fillers are gel-like solutions that are injected beneath the skin to fill in wrinkles and creases, add additional volume to the face, and augment certain features. Dermal fillers contain different active ingredients, but the most common is hyaluronic acid (HA), a naturally occurring chemical with a strong ability to bind with water and draw moisture. Manufacturers also alter the HA structure and include additional compounds to curate formulas to specific facial concerns.

Biostimulators

Biostimulators are injectable solutions that work with the body’s own repair functions. What makes biostimulators unique is that as the body naturally breaks down the solution, it replaces it with collagen, allowing you to enhance structure and texture with your own healing. However, this also means that these injectables offer gradual results rather than immediate improvements. Common biostimulatory materials include calcium hydroxylapatite (CaHA) and poly-L-lactic acid (PLLA).

Neurotoxins

Neurotoxins are specialized injectables that smooth your skin and soften the appearance of facial wrinkles, creases, and fine lines. Neurotoxins inhibit the release of the neurotransmitter responsible for the repeated muscle movements, which eventually lead to the development of deep lines and creases. By inhibiting this release, you can address both existing concerns as well as those that have yet to form. Each neurotoxin formulation contains the protein botulinum toxin A, which comes from the bacterium Clostridium botulinum. ⁽¹⁾

Fillers

Restylane

Restylane (Restylane®) is a family of dermal fillers that target visible signs of aging around different regions of the face. These fillers are HA-based, and they effectively address concerns such as thinning lips, volume loss around the cheeks, and more. Restylane formulations feature either NASHA® or XpresHAn™ technology. NASHA®, or non-animal stabilized hyaluronic acid, provides a firmer texture to improve targeted projection, precision, and structure. On the other hand, XpresHAn™ technology provides flexible support that integrates into the tissues. ⁽²⁾

Restylane Lyft

Restylane Lyft is a member of the Restylane family that can address lost volume in the face, soften the appearance of laugh lines, add structure to the cheeks, elevate the cheekbones, and create a more refreshed appearance overall. Compared to other Restylane products, Restylane Lyft is thicker to better correct deeper, structural issues with longer-lasting effects.

Restylane Silk

Restylane Silk enhances lip appearance by smoothing lines and wrinkles around the mouth and subtly plumping the lips. It features NASHA® technology, creating pronounced results that still look and feel natural.

Restylane Kysse

Restylane Kysse is a specific formulation of Restylane designed to add volume to your lips and fill in fine lines in the perioral region. It features XpresHAn™ technology that allows the filler to naturally move with facial expressions. What makes this filler unique is that it can adapt to heat, muscle contractions, and other conditions affecting your lips, restoring a plumper, more desirable pout with a durable, stable solution.

Restylane Refyne & Defyne

Restylane Refyne & Defyne are the newest HA-based fillers in the Restylane family. These fillers can address deeper creases and lines such as nasolabial folds, marionette lines, facial hollowing, or sunken areas beneath the eyes.

Evolysse™ Form & Smooth

Evolysse™ is a HA-based injectable that can smooth and soften smile and laugh lines. This injectable is made in cold temperatures using Cold-X™ technology, which preserves the molecular structure of the natural hyaluronic acid. This retains the integrity of the HA chains, leading to a more natural look and feel. ⁽³⁾

Obagi® MagIQ™

Obagi® MagIQ™ can address moderate-to-severe facial wrinkles and folds across different regions of the face, including deep nasolabial folds or marionette folds. This HA-based filler can address concerns across all skin types and offers the most consistent particle size. ⁽⁴⁾

Biostimulators

Radiesse

Radiesse® is a biostimulator composed of calcium-based microspheres suspended in a water-based gel. This injectable is ideal for addressing areas such as smile lines, nasolabial folds, and other wrinkles around the nose and mouth. Radiesse is considered a semipermanent filler, as it has a longer duration of effect compared to many other injectables. ⁽⁵⁾ Upon injection, it stimulates the production of new collagen in the area. This then slowly replaces the filler to provide more support and restore the firmness and elasticity of your skin.

PDO Thread Lift

PDO thread lifting is a unique treatment that uses biodegradable threads composed of polydioxanone to lift sagging skin and promote the new production of collagen. ⁽⁶⁾ This treatment is often performed as a non-surgical alternative to facelifting. It elevates the position of the skin to address laxity across the neck or chin, sharpen the appearance of the jawline, reduce nasolabial folds and marionette lines, lift the brows, elevate the cheeks, or reduce under-eye wrinkles.

Sculptra

Sculptra® is a semi-permanent injectable composed of poly-L-lactic acid, a type of biocompatible and biodegradable filler. When injected, Sculptra adds volume to the target area and stimulates the gradual formation of collagen. ⁽⁷⁾ This effectively addresses volume loss and wrinkles that may have developed around several regions of the face.

Neurotoxins

Botox

Botox (BOTOX®) restores a more youthful-looking appearance by addressing the dynamic facial movements responsible for the formation of wrinkles and creases across your under-eyes, forehead, and brow. It works by blocking certain neurotransmitters, allowing your skin to relax and smooth itself out. ⁽⁸⁾ This means that you can not only address your existing signs of aging, but also reduce those that have yet to form.

Dysport

Dysport® is an injectable treatment similar to Botox, but its formulation contains smaller molecules. This means that it has a different unit measurement, but it also spreads more easily to cover larger areas, and it has a faster onset time.

Xeomin

Xeomin® is derived from the same protein as both Botox and Dysport, but it does not contain any complexing proteins. ⁽⁹⁾ These are the nontoxic proteins that protect and facilitate the absorption of the botulinum toxin A, but they can also cause your body to build up a gradual tolerance towards the treatment. With Xeomin, you can achieve the same rejuvenation as Botox and Dysport, but it will remain effective every time.

Letybo

Letybo® is a newer injectable that can address the appearance of glabellar lines, or the lines found between the eyebrows. This solution is also derived from the same protein as Botox, and it is the #1 injectable in South Korea, making it a staple Korean Beauty treatment. ⁽¹⁰⁾

Personal Consultation

The first step to restoring a more youthful-looking and sculpted appearance is attending a personal consultation. During your visit, one of our expert injection specialists will meet with you to review your medical history, discuss your concerns, and learn more about your aesthetic goals. They will also assess your facial anatomy and skin quality. Using this information, they will help you determine which injection is best for you and tailor your treatment plan accordingly.

If you are ready to schedule this consultation, please contact us online or call your closest office:

Cost of Dermal Fillers and Injectables in Southern California

The cost of your dermal fillers and injectables will vary depending on certain factors, including the exact product and amount you receive. Once you have met with your specialist to discuss and establish each of these details, they will provide you with a comprehensive cost estimate.

References

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2. Restylane® Science & Technology.; 2023. Accessed July 23, 2026. https://www.restylaneusa.com/restylane-science
3. Evolysse Difference. 2024. Accessed August 18, 2026. https://evolysse.evolus.com/evolysse-difference
4. Obagi. Obagi. 2026. Accessed August 18, 2026. https://www.obagi.com/pages/obagi-magiq-hyaluronic-acid-filler?srsltid=AfmBOopzesBF2J9C1YevZYVnkkl3tHw3o2bbBRsSp_bDgGPeCc-9I81u
5. Sánchez-Carpintero I, Candelas D, Ruiz-Rodríguez R. Dermal Fillers: Types, Indications, and Complications. Actas Dermo-Sifiliográficas (English Edition). 2010;101(5):381-393. doi:10.1016/S1578-2190(10)70660-0
6. Tamura T, Okumura K, Funakoshi Y, Teranishi H. Multicenter Review of More Than 110,000 Facial Thread Lifting Cases From a Cosmetic Surgery Group. Plastic and Reconstructive Surgery – Global Open. 2025;13(12):e7335. doi:10.1097/gox.0000000000007335
7. Haddad A, Avelar L, Fabi SG, et al. Injectable Poly-l-Lactic Acid for Body Aesthetic Treatments: An International Consensus on Evidence Assessment and Practical Recommendations. Aesthetic Plastic Surgery. Published online November 26, 2024. doi:10.1007/s00266-024-04499-9
8. Padda IS, Tadi P. Botulinum Toxin. StatPearls Publishing; 2023. Accessed July 23, 2026. https://www.ncbi.nlm.nih.gov/books/NBK557387/
9. Frevert J. Xeomin®: an innovative new botulinum toxin type A. European Journal of Neurology. 2009;16:11-13. doi:10.1111/j.1468-1331.2009.02879.x
10. Mueller DS, Prinz V, Adelglass J, et al. Efficacy and Safety of Letibotulinumtoxin A in the Treatment of Glabellar Lines: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Phase 3 Study. Aesthetic Surgery Journal. 2022;42(6):677. Accessed August 18, 2026. https://pmc.ncbi.nlm.nih.gov/articles/PMC13267890/#s16